Article
The Bioinformatics Report of Mutation Outcome on NADPH Flavin Oxidoreductase Protein Sequence in Clinical Isolates of H. pylori.
Current microbiology - 1 May 2016
Mirzaei Nasrin, Poursina Farkhondeh, Moghim Sharareh, Ghaempanah Abdol Majid, Safaei Hajieh Ghasemian
Abstract excerpt
frxA gene has been implicated in the metronidazole nitro reduction by H. pylori. Alternatively, frxA is expected to contribute to the protection of urease and to the in vivo survival of H. pylori. The aim of present study is to report the mutation effects on the frxA protein sequence in clinical isolates of H. pylori in our community. Metronidazole resistance was proven in 27 of 48 isolates. glmM and frxA genes...
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