Pre-clinical use of isogenic cell lines and tumours in vitro and in vivo for predictive biomarker discovery; impact of KRAS and PI3KCA mutation status on MEK inhibitor activity is model dependent.

doi:10.1016/j.ejca.2015.12.012

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Article

Pre-clinical use of isogenic cell lines and tumours in vitro and in vivo for predictive biomarker discovery; impact of KRAS and PI3KCA mutation status on MEK inhibitor activity is model dependent.

European journal of cancer (Oxford, England : 1990) - 1 Mar 2016

Haagensen Emma J, Thomas Huw D, Mudd Clare, Tsonou Elpida, Wiggins Ceri M, Maxwell Ross J, Moore Jonathan D, Newell David R

Abstract excerpt

Studies to identify predictive biomarkers can be carried out in isogenic cancer cell lines, which enable interrogation of the effect of a specific mutation. We assessed the effects of four drugs, the PI3K-mammalian target of rapamycin inhibitor dactolisib, the PI3K inhibitor pictrelisib, and the MEK (MAPK/ERK Kinase) inhibitors PD 0325901 and selumetinib, in isogenic DLD1 parental, KRAS(+/-), KRAS(G13D/-),...

Topics

Animals
Antineoplastic Agents
Biomarkers, Tumor
Cell Line, Tumor
Cell Proliferation
Class I Phosphatidylinositol 3-Kinases
Colorectal Neoplasms
Dose-Response Relationship, Drug
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

MAP Kinase Kinase Kinases

Mice, Nude

Mutation

Phosphatidylinositol 3-Kinases

Phosphoinositide-3 Kinase Inhibitors

Protein Kinase Inhibitors

Proto-Oncogene Proteins p21(ras)

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 26820797
DOI: 10.1016/j.ejca.2015.12.012

Genes

KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-26820797-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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