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Article

Effects of palbociclib on oral squamous cell carcinoma and the role of PIK3CA in conferring resistance

1 Jan 2019

Abstract excerpt

Objective Lack of effective therapies remains a problem in the treatment of oral squamous cell carcinoma (OSCC), especially in patients with advanced tumors. OSCC development is driven by multiple aberrancies within the cell cycle pathway, including amplification of cyclin D1 and loss of p16. Hence, cell cycle inhibitors of the CDK4/6-cyclin D axis are appealing targets for OSCC treatment. Here, we determined the...

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PMID: 31516747
DOI: 10.20892/j.issn.2095-3941.2018.0257

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