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p27kip1 expression and phosphorylation dictate Palbociclib sensitivity in KRAS-mutated colorectal cancer.

Cell death & disease - 15 Oct 2021

Rampioni Vinciguerra Gian Luca, Dall'Acqua Alessandra, Segatto Ilenia, Mattevi Maria Chiara, Russo Francesca, Favero Andrea, Cirombella Roberto, Mungo Giorgia, Viotto Davide, Karimbayli Javad, Pesce Margherita, Vecchione Andrea, Belletti Barbara, Baldassarre Gustavo

Abstract excerpt

In colorectal cancer, mutation of KRAS (RASMUT) reduces therapeutic options, negatively affecting prognosis of the patients. In this setting, administration of CDK4/6-inhibitors, alone or in combination with other drugs, is being tested as promising therapeutic strategy. Identifying sensitive patients and overcoming intrinsic and acquired resistance to CDK4/6 inhibition represent still open challenges, to obtain...

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PMID: 34654798
DOI: 10.1038/s41419-021-04241-2
PMCID: PMC8519959

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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