Article

Preclinical Drug Testing of the CDK 4/6 Inhibitor Palbociclib in Combination With a PI3K or MEK Inhibitor in Colorectal Cancer Cell Lines

2021-06-23

Abstract excerpt

<title>Abstract</title> <p>Background: Studies have demonstrated the efficacy of Palbociclib (CDK 4/6 inhibitor), Gedatolisib (PI3K/mTOR dual inhibitor) and PD0325901 (MEK1/2 inhibitor) in colorectal cancer (CRC), however single agent therapeutics are often limited by resistance. The main purpose of this in vitro study is to comprehensively test two drug combinations [Palbociclib with Gedatolisib (P+G) and Palboc...

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Literature Corpus work: e6be7244-a8de-5456-81ab-31ca9971bb82
DOI: 10.21203/rs.3.rs-647758/v1

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