Article
Development of an integrated genomic classifier for a novel agent in colorectal cancer: approach to individualized therapy in early development.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2010
Pitts Todd M, Tan Aik Choon, Kulikowski Gillian N, Tentler John J, Brown Amy M, Flanigan Sara A, Leong Stephen, Coldren Christopher D, Hirsch Fred R, Varella-Garcia Marileila, Korch Christopher, Eckhardt S Gail
Abstract excerpt
BACKGROUND: A plethora of agents is in early stages of development for colorectal cancer (CRC), including those that target the insulin-like growth factor I receptor (IGFIR) pathway. In the current environment of numerous cancer targets, it is imperative that patient selection strategies be developed with the intent of preliminary testing in the latter stages of phase I trials. The goal of this study was to...
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