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Article

Deer Prion Proteins Modulate the Emergence and Adaptation of Chronic Wasting Disease Strains.

Journal of virology - 1 Dec 2015

Duque Velásquez Camilo, Kim Chiye, Herbst Allen, Daude Nathalie, Garza Maria Carmen, Wille Holger, Aiken Judd, McKenzie Debbie

Abstract excerpt

UNLABELLED: Transmission of chronic wasting disease (CWD) between cervids is influenced by the primary structure of the host cellular prion protein (PrP(C)). In white-tailed deer, PRNP alleles encode the polymorphisms Q95 G96 (wild type [wt]), Q95 S96 (referred to as the S96 allele), and H95 G96 (referred to as the H95 allele), which differentially impact CWD progression. We hypothesize that the transmission of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26423950
DOI: 10.1128/JVI.02010-15
PMCID: PMC4665243

Genes

PRNP

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