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Article

Sample-size properties of a case-control association analysis of multistage SNP studies for identifying disease susceptibility genes.

Journal of human genetics - 1 Jan 2008

Kitamura Nobutaka, Akazawa Kouhei, Toyabe Shin-Ichi, Miyashita Akinori, Kuwano Ryozo, Nakamura Junichiro

Abstract excerpt

A two-stage association study is the most commonly used method to efficiently identify disease susceptibility genes. However, some recent single nucleotide polymorphism (SNP) studies recently utilized three-stage designs. The purpose of this study was to investigate the practical properties of statistical powers and positive predictive values (PPVs) of replication-based analysis (RBA) and the joint analysis (JA)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18288444
DOI: 10.1007/s10038-008-0258-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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