Inference of domain-disease associations from domain-protein, protein-disease and disease-disease relationships.

Abstract excerpt

BACKGROUND: Protein domains can be viewed as portable units of biological function that defines the functional properties of proteins. Therefore, if a protein is associated with a disease, protein domains might also be associated and define disease endophenotypes. However, knowledge about such domain-disease relationships is rarely available. Thus, identification of domains associated with human diseases would...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Area Under Curve
• Share to Bayes Theorem
• Share to Crohn Disease