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Article

Predicting nsSNPs that Disrupt Protein-Protein Interactions Using Docking.

IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000

Goodacre Norman, Edwards Nathan, Danielsen Mark, Uetz Peter, Wu Cathy

Abstract excerpt

The human genome contains a large number of protein polymorphisms due to individual genome variation. How many of these polymorphisms lead to altered protein-protein interaction is unknown. We have developed a method to address this question. The intersection of the SKEMPI database (of affinity constants among interacting proteins) and CAPRI 4.0 docking benchmark was docked using HADDOCK, leading to a training...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26812731
DOI: 10.1109/TCBB.2016.2520931

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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