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Article

Single-gene association between GATA-2 and autoimmune hepatitis: A novel genetic insight highlighting immunologic pathways to disease.

Journal of hepatology - 1 May 2016

Webb Gwilym, Chen Yung-Yi, Li Ka-Kit, Neil Desley, Oo Ye Htun, Richter Alex, Bigley Venetia, Collin Matthew, Adams David H, Hirschfield Gideon M

Abstract excerpt

Background & Aims Autoimmune hepatitis (AIH), an immune-mediated liver disease, originates as a consequence of interacting genetic and environmental risk factors. Treatment remains non-specific and prone to side effects. Deficiencies in regulatory T cell (Treg) function are hypothesized to contribute to the pathogenesis of AIH. Methods We describe an adult patient who presented with AIH in the context of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26812071
DOI: 10.1016/j.jhep.2016.01.017
PMCID: PMC4824751

Genes

GATA2
FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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