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Article

FoxP3: a genetic link between immunodeficiency and autoimmune diseases.

Autoimmunity reviews - 1 Jul 2006

Chang Xing, Zheng Pan, Liu Yang

Abstract excerpt

It has long been observed that patients with autoimmune diseases also have immune deficiency. How these two opposite extremes of immunity can be found in the same individual is largely unclear. Here we review the evidence that a FoxP3 defect may provide a critical link between autoimmunity and immune deficiency. Disruption of FoxP3 results in severe autoimmune syndromes in both human and mice. Bone marrow chimera...

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Identifiers

PMID: 16890893
DOI: 10.1016/j.autrev.2005.10.008

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