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Article

GATA-3 in Human T Cell Helper Type 2 Development

2 Feb 2004

Abstract excerpt

The delineation of the in vivo role of GATA-3 in human T cell differentiation is a critical step in the understanding of molecular mechanisms directing human immune responses. We examined T cell differentiation and T cell-mediated effector functions in individuals lacking one functional GATA-3 allele. CD4 T cells from GATA-3+/- individuals expressed significantly reduced levels of GATA-3, associated with markedly...

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PMID: 14757746
DOI: 10.1084/jem.20031323

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