CELF4 Variant and Anthracycline-Related Cardiomyopathy: A Children's Oncology Group Genome-Wide Association Study.

doi:10.1200/JCO.2015.63.4550

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Article

CELF4 Variant and Anthracycline-Related Cardiomyopathy: A Children's Oncology Group Genome-Wide Association Study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Mar 2016

Wang Xuexia, Sun Can-Lan, Quiñones-Lombraña Adolfo, Singh Purnima, Landier Wendy, Hageman Lindsey, Mather Molly, Rotter Jerome I, Taylor Kent D, Chen Yii-Der Ida, Armenian Saro H, Winick Naomi, Ginsberg Jill P, Neglia Joseph P, Oeffinger Kevin C, Castellino Sharon M, Dreyer Zoann E, Hudson Melissa M, Robison Leslie L, Blanco Javier G, Bhatia Smita

Abstract excerpt

PURPOSE: Interindividual variability in the dose-dependent association between anthracyclines and cardiomyopathy suggests that genetic susceptibility could play a role. The current study uses an agnostic approach to identify genetic variants that could modify cardiomyopathy risk. METHODS: A genome-wide association study was conducted in childhood cancer survivors with and without cardiomyopathy (cases and...

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Identifiers

PMID: 26811534
DOI: 10.1200/JCO.2015.63.4550
PMCID: PMC5070560

Genes

TNNT2
CELF4

Provenance

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