Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes--a report from the Children's Oncology Group.

doi:10.1200/JCO.2011.34.8987

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Article

Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes--a report from the Children's Oncology Group.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 May 2012

Blanco Javier G, Sun Can-Lan, Landier Wendy, Chen Lu, Esparza-Duran Diego, Leisenring Wendy, Mays Allison, Friedman Debra L, Ginsberg Jill P, Hudson Melissa M, Neglia Joseph P, Oeffinger Kevin C, Ritchey A Kim, Villaluna Doojduen, Relling Mary V, Bhatia Smita

Abstract excerpt

PURPOSE: Carbonyl reductases (CBRs) catalyze reduction of anthracyclines to cardiotoxic alcohol metabolites. Polymorphisms in CBR1 and CBR3 influence synthesis of these metabolites. We examined whether single nucleotide polymorphisms in CBR1 (CBR1 1096G>A) and/or CBR3 (CBR3 V244M) modified the dose-dependent risk of anthracycline-related cardiomyopathy in childhood cancer survivors. PATIENTS AND METHODS: One...

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Identifiers

PMID: 22124095
DOI: 10.1200/JCO.2011.34.8987
PMCID: PMC3383117

Genes

CBR3
CBR1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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