Article
Role of UTS2 gene in the genetic susceptibility to atrial fibrillation in the Chinese population.
Postgraduate medical journal - 1 Apr 2016
Zhao Jing, Ding Wen-Hui, Chu Song-Yun, Jiang Jie, Zhou Jing, Xia Yu-Long, Wu Lin
Abstract excerpt
OBJECTIVE: Atrial fibrosis plays a key role in the inducibility and persistence of atrial fibrillation. Urotensin II (U-II/UTS2) induces cardiac fibrosis by increasing fibroblast collagen synthesis and increased U-II plasma levels have been reported in patients with atrial fibrosis. Our objective was therefore to evaluate the possible role of the UTS2 gene polymorphisms Thr21Met and Ser89Asn in the genetic...
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