Article
A Functional Single-Nucleotide Polymorphism in Pre-microRNA-196a2 is Associated with Atrial Fibrillation in Han Chinese.
Clinical laboratory - 1 Jan 2015
Su Ya-Min, Li Jun, Guo Yun-Feng, Cai Fei, Cai Xing-Xing, Pan Hai-Yan, Deng Xin-Tao, Pan Min
Abstract excerpt
BACKGROUND: MicroRNAs are small, single-stranded, non-protein-coding RNAs of about 22 nucleotides. MicroRNA molecules have been identified to play key roles in a broad range of physiologic and pathologic processes. Polymorphisms in the corresponding sequence space are likely to make a significant contribution to phenotypic variation. A T/C genetic variant (rs11614913) in the pre-miR-196a2 sequence could alter...
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