Article
Association between Thr21Met and Ser89Asn polymorphisms of the urotensin II gene and systemic sclerosis.
The Journal of rheumatology - 1 Jan 2012
Pehlivan Yavuz, Gogebakan Bulent, Oztuzcu Serdar, Ozgen Metin, Cetin Gözde Yildirim, Bayraktar Recep, Cengiz Beyhan, Kisacik Bunyamin, Koca Suleyman Serdar, Donmez Salim, Sayarlioglu Mehmet, Demiryurek Abdullah T, Onat Ahmet Mesut
Abstract excerpt
OBJECTIVE: Systemic sclerosis (SSc) is an autoimmune chronic fibrotic disorder. Urotensin II (U-II) is predominantly a vasoactive peptide with fibrotic and prothrombotic features. Like endothelin-1 (ET-1), U-II could play an important role in SSc pathogenesis. We evaluated the possible role of the U-II gene polymorphisms (Thr21Met and Ser89Asn) in the genetic susceptibility to SSc in a Turkish population....
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