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Article

The pilT gene contributes to type III ExoS effector injection into epithelial cells in Pseudomonas aeruginosa.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy - 1 Apr 2016

Shikata Mototsugu, Hayashi Naoki, Fujimoto Akiyo, Nakamura Takano, Matsui Naoyuki, Ishiyama Ayana, Maekawa Yui, Gotoh Naomasa

Abstract excerpt

A type IV pilus filament, mainly composed of PilA, is retracted by the driving power generated by PilT and PilU ATPases. pilA is required for injection of type III ExoS effectors into epithelial cells thereby facilitating Pseudomonas aeruginosa penetration through the epithelial barrier by impairing the defense function of tight junctions. Here, we examined whether the pilT and pilU of the P. aeruginosa PAO1...

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Identifiers

PMID: 26809217
DOI: 10.1016/j.jiac.2015.12.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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