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Article

Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics.

The Journal of general physiology - 1 Jan 2013

Terrenoire Cecile, Wang Kai, Tung Kelvin W Chan, Chung Wendy K, Pass Robert H, Lu Jonathan T, Jean Jyh-Chang, Omari Amel, Sampson Kevin J, Kotton Darrell N, Keller Gordon, Kass Robert S

Abstract excerpt

Understanding the basis for differential responses to drug therapies remains a challenge despite advances in genetics and genomics. Induced pluripotent stem cells (iPSCs) offer an unprecedented opportunity to investigate the pharmacology of disease processes in therapeutically and genetically relevant primary cell types in vitro and to interweave clinical and basic molecular data. We report here the derivation of...

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Identifiers

PMID: 23277474
DOI: 10.1085/jgp.201210899
PMCID: PMC3536519

Genes

KCNH2

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