Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evaluation of a commercial real-time PCR kit for the detection of the Q80K polymorphism in plasma from HCV genotype 1a infected patients.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Mar 2016

Vicenti Ilaria, Falasca Francesca, Sticchi Laura, Bruzzone Bianca, Turriziani Ombretta, Zazzi Maurizio

Abstract excerpt

BACKGROUND: Screening of the natural HCV NS3 polymorphism Q80K is required prior to simeprevir administration due to the reduced susceptibility of genotype 1 viruses carrying this amino acid variant. A simple, rapid and robust test for Q80K screening would be advisable in routine diagnostic laboratories. OBJECTIVES: The aim of this study was to evaluate a commercial NS3 Q80K real-time PCR kit (Q80K Polymorphism...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis C, Chronic

Share to Reagent Kits, Diagnostic

Share to Real-Time Polymerase Chain Reaction

Share to Simeprevir

Share to Viral Nonstructural Proteins

Source

Identifiers

PMID: 26802683
DOI: 10.1016/j.jcv.2016.01.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evaluation of a commercial real-time PCR kit for the detection of the Q80K polymorphism in plasma from HCV genotype 1a infected patients.PMID 26802683Read ↗

New real-time-PCR method to identify single point mutations in hepatitis C virus.Semantic proximity Read ↗

Worldwide distribution of the NS3 gene 80K polymorphism among circulating hepatitis C genotype 1 viruses: implication for simeprevir usage.Semantic proximity Read ↗

[Determination of the naturally occurring Q80K mutation in the HCV NS3 protease gene].Semantic proximity Read ↗

Detection of the NS3 Q80K polymorphism by Sanger and deep sequencing in hepatitis C virus genotype 1a strains in the UK.Semantic proximity Read ↗

Prevalence of the hepatitis C virus NS3 polymorphism Q80K in genotype 1 patients in the European region.Semantic proximity Read ↗

Patients eligible for treatment with simeprevir in a French center.Semantic proximity Read ↗

Predominance of hepatitis C virus Q80K among NS3 baseline-resistance-associated amino acid variants in direct-antiviral-agent-naïve patients with chronic hepatitis: single-centre experience.Semantic proximity Read ↗

Evaluation of sequencing of HCV core/E1, NS5A and NS5B as a genotype predictive tool in comparison with commercial assays targeting 5'UTR.Semantic proximity Read ↗

Performance of the Abbott Real-Time PCR Assay Usingm2000spandm2000rtfor Hepatitis C Virus RNA QuantificationSemantic proximity Read ↗

Evaluation of the Roche Diagnostics LightCycler-Apo B 3500 Mutation Detection Kit.Semantic proximity Read ↗

Genotypic analysis of HCV 1a by sequencing of the NS3 proteasic region in simeprevir therapy candidates.Semantic proximity Read ↗

Implementation of a cost-effective unlabeled probe high-resolution melt assay for genotyping of Factor V Leiden.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.