Article
New real-time-PCR method to identify single point mutations in hepatitis C virus.
World journal of gastroenterology - 21 Nov 2016
Chen Qian, Belmonte Irene, Buti Maria, Nieto Leonardo, Garcia-Cehic Damir, Gregori Josep, Perales Celia, Ordeig Laura, Llorens Meritxell, Soria Maria Eugenia, Esteban Rafael, Esteban Juan Ignacio, Rodriguez-Frias Francisco, Quer Josep
Abstract excerpt
AIM: To develop a fast, low-cost diagnostic strategy to identify single point mutations in highly variable genomes such as hepatitis C virus (HCV). METHODS: In patients with HCV infection, resistance-associated amino acid substitutions within the viral quasispecies prior to therapy can confer decreased susceptibility to direct-acting antiviral agents and lead to treatment failure and virological relapse. One such...
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