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Implementation of a cost-effective unlabeled probe high-resolution melt assay for genotyping of Factor V Leiden.

Genetic testing and molecular biomarkers - 1 Apr 2011

Svensson Annika M, Chou Lan-Szu, Meadows Cindy, Miller Christine E, Palais Robert, Sumner Kelli, Wayman Tyler C, Mao Rong, Lyon Elaine

Abstract excerpt

The Factor V Leiden mutation (FVL; c.1601G>A, p.Arg534Gln), the most common aberration underlying activated Protein C resistance, results in disruption of a major anticoagulation pathway and is a leading cause of inherited thrombophilia. A high-throughput assay for FVL mutation detection was deve...

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PMID: 21254846
DOI: 10.1089/gtmb.2010.0137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21254846-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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