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Article

Chromosomal anomalies at 1q, 3, 16q, and mutations of SIX1 and DROSHA genes underlie Wilms tumor recurrences.

Oncotarget - 23 Feb 2016

Spreafico Filippo, Ciceri Sara, Gamba Beatrice, Torri Federica, Terenziani Monica, Collini Paola, Macciardi Fabio, Radice Paolo, Perotti Daniela

Abstract excerpt

Approximately half of children suffering from recurrent Wilms tumor (WT) develop resistance to salvage therapies. Hence the importance to disclose events driving tumor progression/recurrence. Future therapeutic trials, conducted in the setting of relapsing patients, will need to prioritize targets present in the recurrent lesions. Different studies identified primary tumor-specific signatures associated with poor...

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Source

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Identifiers

PMID: 26802027
DOI: 10.18632/oncotarget.6950
PMCID: PMC4891013

Genes

SIX1
DROSHA
SIX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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