Article
Analysis of the mutational status of SIX1/2 and microRNA processing genes in paired primary and relapsed Wilms tumors and association with relapse.
Cancer gene therapy - 1 Sept 2021
Ciceri Sara, Montalvão-de-Azevedo Rafaela, Tajbakhsh Amir, Bertolotti Alessia, Spagnuolo Rosalin Dolores, Boschetti Luna, Capasso Maria, D'Angelo Paolo, Serra Annalisa, Diomedi-Camassei Francesca, Meli Mariaclaudia, Nantron Marilina, Quarello Paola, Buccoliero Anna Maria, Tamburini Angela, Ciniselli Chiara Maura, Verderio Paolo, Collini Paola, Radice Paolo, Spreafico Filippo, Perotti Daniela
Abstract excerpt
Whereas 90% of patients with Wilms tumor (WT) reach cure, approximately half of patients developing a recurrent tumor die of the disease. Therefore, to disclose events leading to recurrence represents a clinical need. To study paired primary/recurrent tumor samples, being aware of the intra-tumoral heterogeneity, might help finding these answers. We previously suggested that mutations in SIX1 and DROSHA underlie...
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