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Article

Uterine leiomyosarcoma progression: A study of serial recurrences.

Gynecologic oncology - 1 Nov 2025

Sia Tiffany Y, Brown David N, Miller Kathryn, Curtin Christina, Selenica Pier, Da Cruz Paula Arnaud, Moufarrij Sara, Abu-Rustum Nadeem R, Leitao Mario M, Chiang Sarah, Weigelt Britta, Hensley Martee L

Abstract excerpt

BACKGROUND: Uterine leiomyosarcomas (uLMS) have high recurrence rates and are frequently characterized by genetic alterations affecting TP53 and RB1. We sought to compare the molecular profiles of primary uLMS and matched serial recurrences to assess tumor evolution. METHODS: Patients diagnosed with uLMS between 1/1/2000-11/31/2020 who had primary tumor, ≥2 serial recurrences, and normal tissue available were...

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Share to Disease Progression
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Recurrence, Local

Share to PTEN Phosphohydrolase

Share to Retinoblastoma Binding Proteins

Share to Tumor Suppressor Protein p53

Share to Ubiquitin-Protein Ligases

Share to Uterine Neoplasms

Source

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Identifiers

PMID: 41027098
DOI: 10.1016/j.ygyno.2025.09.007
PMCID: PMC12649046

Genes

TP53
RB1
ATRX
BRCA2
ESR1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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