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Article

The effects of immunomodulation by macrophage subsets on osteogenesis in vitro.

Stem cell research & therapy - 22 Jan 2016

Loi Florence, Córdova Luis A, Zhang Ruth, Pajarinen Jukka, Lin Tzu-hua, Goodman Stuart B, Yao Zhenyu

Abstract excerpt

BACKGROUND: Bone formation and remodeling are influenced by the inflammatory state of the local microenvironment. In this regard, macrophages are postulated to play a crucial role in modulating osteogenesis. However, the differential effects of macrophage subsets and their plasticity on bone formation are currently unknown. METHODS: Polarized primary murine macrophages and preosteoblastic MC3T3 cells were...

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Identifiers

PMID: 26801095
DOI: 10.1186/s13287-016-0276-5
PMCID: PMC4724110

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