Article
Macrophage M1/M2 polarization dynamically adapts to changes in microenvironment and modulates alveolar bone remodeling after dental implantation.
Journal of leukocyte biology - 1 Sept 2021
Liang Beilei, Wang Haicheng, Wu Di, Wang Zuolin
Abstract excerpt
As one of the first arriving immune cells after dental implantation, Mϕs own the abilities to polarize into to a spectrum of diverse phenotypes, from "classically activated" M1 Mϕs to "alternatively activated" M2 Mϕs. Herein, it was hypothesized that Mϕ phenotypes dynamically adapt after dental implantation, and the changes ensue a cascade of coordinated interplay with the bone-forming osteoblast and the...
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