Article
Monoclonal Antibody RYSK173 Recognizes the Dinuclear Zn Center of Serum Carnosinase 1 (CN-1): Possible Consequences of Zn Binding for CN-1 Recognition by RYSK173.
PloS one - 1 Jan 2016
Zhang Shiqi, Lindner Holger A, Kabtni Sarah, van den Born Jaap, Bakker Stephan, Navis Gerjan, Krämer Bernard, Yard Benito, Hauske Sibylle
Abstract excerpt
BACKGROUND AND AIMS: The proportion of serum carnosinase (CN-1) recognized by RYSK173 monoclonal antibody negatively correlates with CN-1 activity. We thus hypothesized that the epitope recognized by RYSK173 is accessible only in a catalytically incompetent conformation of the zinc dependent enzyme and we mapped its position in the CN-1 structure. Since patients with kidney failure are often deficient in zinc and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.