Article

A Focus on the Metabolic Dysfunction of Proximal Tubule Cells in Dent Disease Type 1

2024-08-01

Abstract excerpt

Dent disease type 1 is a rare inherited renal disorder affecting mainly young males, generally leading to end-stage renal failure and for which there is no cure. It is caused by inactivating mutations in the gene encoding ClC-5, a 2Cl-/H+ exchanger found on endosomes in the renal proximal tubule. This transporter participates in reabsorbing all filtered plasma proteins which justifies why proteinuria is commonly o...

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Literature Corpus work: fd0e6604-9ef9-53b1-8b03-36fd1006f76f
DOI: 10.20944/preprints202408.0048.v1

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