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Article

From protein uptake to Dent disease: An overview of the CLCN5 gene.

Gene - 15 Jul 2020

Gianesello Lisa, Del Prete Dorella, Ceol Monica, Priante Giovanna, Calò Lorenzo Arcangelo, Anglani Franca

Abstract excerpt

Proteinuria is a well-known risk factor, not only for renal disorders, but also for several other problems such as cardiovascular diseases and overall mortality. In the kidney, the chloride channel Cl-/H+ exchanger ClC-5 encoded by the CLCN5 gene is actively involved in preventing protein loss. This action becomes evident in patients suffering from the rare proximal tubulopathy Dent disease because they carry a...

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Share to Cardiac electrophysiology and arrhythmias
Share to Chloride Channels

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Ion channel regulation and function

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Identifiers

PMID: 32289351
DOI: 10.1016/j.gene.2020.144662
PMCID: PMC7402612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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