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Article

Frequency and clinicopathologic profile of PIK3CA mutant GISTs: molecular genetic study of 529 cases.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2016

Lasota Jerzy, Felisiak-Golabek Anna, Wasag Bartosz, Kowalik Artur, Zięba Sebastian, Chłopek Małgorzata, Wang Zeng-Feng, Coates Tiffany, Kopczynski Janusz, Gozdz Stanislaw, Sarlomo-Rikala Maarit, Miettinen Markku

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors usually driven by the mutational activation of receptor tyrosine kinases, KIT, or PDGFRA. Oncogenic activation of phosphatidylinositide-3-kinase (PI3K), a downstream effector in the KIT signaling pathway, has been identified in different types of cancer, with the PI3K 110α subunit encoded by PIK3CA being a common mutational target. In this study, the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26796526
DOI: 10.1038/modpathol.2015.160
PMCID: PMC7511989

Genes

KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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