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Article

Extensive Positive Selection Drives the Evolution of Nonstructural Proteins in Lineage C Betacoronaviruses.

Journal of virology - 20 Jan 2016

Forni Diego, Cagliani Rachele, Mozzi Alessandra, Pozzoli Uberto, Al-Daghri Nasser, Clerici Mario, Sironi Manuela

Abstract excerpt

UNLABELLED: Middle East respiratory syndrome-related coronavirus (MERS-CoV) spreads to humans via zoonotic transmission from camels. MERS-CoV belongs to lineage C of betacoronaviruses (betaCoVs), which also includes viruses isolated from bats and hedgehogs. A large portion of the betaCoV genome consists of two open reading frames (ORF1a and ORF1b) that are translated into polyproteins. These are cleaved by viral...

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Identifiers

PMID: 26792741
DOI: 10.1128/JVI.02988-15
PMCID: PMC4794664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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