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Article

The heptad repeat region is a major selection target in MERS-CoV and related coronaviruses.

Scientific reports - 25 Sept 2015

Forni Diego, Filippi Giulia, Cagliani Rachele, De Gioia Luca, Pozzoli Uberto, Al-Daghri Nasser, Clerici Mario, Sironi Manuela

Abstract excerpt

Middle East respiratory syndrome coronavirus (MERS-CoV) originated in bats and spread to humans via zoonotic transmission from camels. We analyzed the evolution of the spike (S) gene in betacoronaviruses (betaCoVs) isolated from different mammals, in bat coronavirus populations, as well as in MERS-CoV strains from the current outbreak. Results indicated several positively selected sites located in the region...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Middle East Respiratory Syndrome Coronavirus

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Share to Repetitive Sequences, Nucleic Acid

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Source

Open in PubMed Open full text

Identifiers

PMID: 26404138
DOI: 10.1038/srep14480
PMCID: PMC4585914

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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