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Positive selection within the genomes of SARS-CoV-2 and other Coronaviruses independent of impact on protein function

16 Oct 2020

Abstract excerpt

BACKGROUND: The emergence of a novel coronavirus (SARS-CoV-2) associated with severe acute respiratory disease (COVID-19) has prompted efforts to understand the genetic basis for its unique characteristics and its jump from non-primate hosts to humans. Tests for positive selection can identify apparently nonrandom patterns of mutation accumulation within genomes, highlighting regions where molecular function may...

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PMID: 33088633
DOI: 10.7717/peerj.10234

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