Article
Establishment of a DNA methylation marker to evaluate cancer cell fraction in gastric cancer.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Apr 2016
Zong Liang, Hattori Naoko, Yoda Yukie, Yamashita Satoshi, Takeshima Hideyuki, Takahashi Takamasa, Maeda Masahiro, Katai Hitoshi, Nanjo Sohachi, Ando Takayuki, Seto Yasuyuki, Ushijima Toshikazu
Abstract excerpt
BACKGROUND: Tumor samples are unavoidably contaminated with coexisting normal cells. Here, we aimed to establish a DNA methylation marker to estimate the fraction of gastric cancer (GC) cells in any DNA sample by isolating genomic regions specifically methylated in GC cells. METHODS: Genome-wide and gene-specific methylation analyses were conducted with an Infinium HumanMethylation450 BeadChip array and by...
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