Article
Search for Genetic Variant in the Apelin Gene by Resequencing and Association Study in European Subjects.
Genetic testing and molecular biomarkers - 1 Feb 2016
Sentinelli Federica, Capoccia Danila, Bertoccini Laura, Barchetta Ilaria, Incani Michela, Coccia Federica, Manconi Ettore, Lenzi Andrea, Cossu Efisio, Leonetti Frida, Cavallo Maria Gisella, Baroni Marco Giorgio
Abstract excerpt
AIMS: Apelin is a peptide produced and secreted by white adipose tissue. It is synthesized as preproapelin, a protein containing 77 aminoacids which is then cleaved to shorter active fragments. As an adipokine, apelin plays a role in the regulation of many biological functions, including body energy homeostasis and glucose metabolism, water balance, and immunity. We have recently demonstrated that subjects with...
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