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Validation of genetic association in apelin-AGTRL1 system with hypertension in a larger Han Chinese population.

Journal of hypertension - 1 Sept 2010

Niu Wenquan, Wu Shengnan, Zhang Yi, Li Weiwei, Ji Kaida, Gao Pingjin, Zhu Dingliang

Abstract excerpt

BACKGROUND AND OBJECTIVE: We have recently resequenced apelin and AGTRL1 genes to identify candidate polymorphisms in family-based association with hypertension and related phenotypes. In this study, we aimed to determine and replicate these polymorphisms via a larger, independent case-control study in Shanghai Han Chinese. METHODS: Two polymorphisms [rs3761581 (A/C) and T-1860C] in apelin gene and two [rs7119375...

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PMID: 20485192
DOI: 10.1097/HJH.0b013e32833b1fad

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