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Article

MYC-Mediated Functional Manifestation of IDH1 Mutations in Intrahepatic Cholangiocarcinoma Confers Sensitivity to (+)-JQ1.

International journal of biological sciences - 1 Jan 2026

Wang Fangyanni, Liu Xinyu, Zhang Ning, Kong Ruirui

Abstract excerpt

Intrahepatic cholangiocarcinoma (ICC) is one of most aggressive malignancies attributable to limited treatment options. IDH1 is commonly mutated and frequently cooccurred with other genetic alterations in ICC. The mechanism by which they affect ICC patient prognosis and therapeutic resistance remains incompletely understood. We aimed to investigate the function of MYC in IDH1mutant ICC progression and develop the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41800252
DOI: 10.7150/ijbs.123085
PMCID: PMC12965060

Genes

MYC
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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MYC-Mediated Functional Manifestation of IDH1 Mutations in Intrahepatic Cholangiocarcinoma Confers Sensitivity to (+)-JQ1.PMID 41800252Read ↗

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