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Article

Mobile small RNAs regulate genome-wide DNA methylation.

Proceedings of the National Academy of Sciences of the United States of America - 9 Feb 2016

Lewsey Mathew G, Hardcastle Thomas J, Melnyk Charles W, Molnar Attila, Valli Adrián, Urich Mark A, Nery Joseph R, Baulcombe David C, Ecker Joseph R

Abstract excerpt

RNA silencing at the transcriptional and posttranscriptional levels regulates endogenous gene expression, controls invading transposable elements (TEs), and protects the cell against viruses. Key components of the mechanism are small RNAs (sRNAs) of 21-24 nt that guide the silencing machinery to their nucleic acid targets in a nucleotide sequence-specific manner. Transcriptional gene silencing is associated with...

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Identifiers

PMID: 26787884
DOI: 10.1073/pnas.1515072113
PMCID: PMC4760824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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