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Article

Exhausted T cell phenotypes in disseminated coccidioidomycosis.

JCI insight - 22 May 2026

Whitehill Gregory D, Stephens Alexis V, Thauland Timothy J, Moreno Lastre Miguel A, Tate Matthew M, Beyhan Sinem, Johnson Royce H, Thompson George R, Garcia-Lloret Maria, Butte Manish J

Abstract excerpt

BACKGROUNDCoccidioidomycosis ranges from self-limiting uncomplicated Valley fever (UVF) in most cases to life-threatening disseminated coccidioidomycosis (DCM) in rare individuals. A few patterns of immunologic deficits allowing for dissemination have been identified, although the specific defects in most individuals with DCM remain undefined. We hypothesized that chronic antigen exposure in DCM engenders a state...

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Identifiers

PMID: 42171605
DOI: 10.1172/jci.insight.203270
PMCID: PMC13232714

Genes

CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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