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Article

Sepsis leads to lasting changes in phenotype and function of memory CD8 T cells.

eLife - 15 Oct 2021

Jensen Isaac J, Li Xiang, McGonagill Patrick W, Shan Qiang, Fosdick Micaela G, Tremblay Mikaela M, Houtman Jon Cd, Xue Hai-Hui, Griffith Thomas S, Peng Weiqun, Badovinac Vladimir P

Abstract excerpt

The global health burden due to sepsis and the associated cytokine storm is substantial. While early intervention has improved survival during the cytokine storm, those that survive can enter a state of chronic immunoparalysis defined by transient lymphopenia and functional deficits of surviving cells. Memory CD8 T cells provide rapid cytolysis and cytokine production following re-encounter with their cognate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34652273
DOI: 10.7554/eLife.70989
PMCID: PMC8589447

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