Article
Increased PD-1 Expression and Altered T Cell Repertoire Diversity Predict Mortality in Patients with Septic Shock: A Preliminary Study.
PloS one - 1 Jan 2017
Tomino Atsutoshi, Tsuda Masanobu, Aoki Ruri, Kajita Yuka, Hashiba Masamitsu, Terajima Tsuguaki, Kano Hideki, Takeyama Naoshi
Abstract excerpt
Sepsis causes impairment of innate and adaptive immunity by multiple mechanisms, including depletion of immune effector cells and T cell exhaustion. Although lymphocyte dysfunction is associated with increased mortality and potential reactivation of latent viral infection in patients with septic shock, the relation between viral reactivation and lymphocyte dysfunction is obscure. The objectives of this study were...
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