Article
A Whole Blood Enzyme-Linked Immunospot Assay for Functional Immune Endotyping of Septic Patients.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2021
Mazer Monty B, C Caldwell Charles, Hanson Jodi, Mannion Daniel, Turnbull Isaiah R, Drewry Anne, Osborne Dale, Walton Andrew, Blood Tessa, Moldawer Lyle L, Brakenridge Scott, Remy Kenneth E, Hotchkiss Richard S
Abstract excerpt
Sepsis initiates simultaneous pro- and anti-inflammatory processes, the pattern and intensity of which vary over time. The inability to evaluate the immune status of patients with sepsis in a rapid and quantifiable manner has undoubtedly been a major reason for the failure of many therapeutic trials. Although there has been considerable effort to immunophenotype septic patients, these methods have often not...
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