PD-L1 mediated T cell inhibition by regulatory plasma cells induced after sepsis and COVID-19

Abstract excerpt

A better understanding of sepsis-induced immunosuppression pathophysiology is desirable for the development of novel therapeutic strategies to prevent and reduce the rates of secondary infections and their associated mortality. Here we demonstrate that PD-L1 + CD44 + B220 Low CD138 + IgM + regulatory plasma cells (PCs) are induced in a murine model of sepsis-induced immune alterations and in critically ill patient...

Topics

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• Adrenal Cortex Hormones
• Betacoronavirus
• Blood Coagulation Disorders
• Coronavirus Infections
• Diabetes and associated disorders
• Immune System
• Lymphopenia
• Sepsis Diagnosis and Treatment

Identifiers and source

Literature Corpus work

279090a4-7344-5811-8a5c-6c195d61582e

DOI

10.1101/2024.08.08.24311630