Article
Axonal motor protein KIF5A and associated cargo deficits in multiple sclerosis lesional and normal-appearing white matter.
Neuropathology and applied neurobiology - 1 Apr 2017
Hares K, Redondo J, Kemp K, Rice C, Scolding N, Wilkins A
Abstract excerpt
AIMS: Understanding the causes of axonal pathology remains a key goal in the pursuit of new therapies to target disease progression in multiple sclerosis (MS). Anterograde axonal transport of many proteins vital for axonal viability is mediated by the motor protein KIF5A, which has been linked to several neurological diseases. This study aimed to investigate the expression of KIF5A protein and its associated...
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