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Article

ALS Mutations Shift the Isoelectric Point of the KIF5A C Terminal Inducing Protein Aggregation and TDP-43 Mislocalization.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 Jul 2025

Zanella Pietro, Loss Isabel, Parlato Rosanna, Weishaupt Jochen H, Sala Carlo, Verpelli Chiara, Boeckers Tobias M, Catanese Alberto

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by death of lower and upper motor neurons. Although the mechanism behind the selective neuron loss is still unclear, several heterogeneous genes have been causally linked to ALS. KIF5A encodes for a neuronally enriched kinesin involved in protein transport, and mutations within this gene have been causally linked to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40555518
DOI: 10.1523/JNEUROSCI.1658-24.2025
PMCID: PMC12311770

Genes

KIF5A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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