Article

Targeted plasma proteomics uncover novel proteins associated with <i>KIF5A</i> -linked SPG10 and ALS spectrum disorders

2025-05-02

Abstract excerpt

KIF5A (Kinesin family member 5A) is a motor protein that functions as a key component of the axonal transport machinery. Variants in KIF5A are linked to several neurodegenerative diseases, mainly spastic paraplegia type 10 (SPG10), Charcot-Marie-Tooth disease type 2 (CMT2), and amyotrophic lateral sclerosis (ALS). These diseases share motor neuron involvement but vary significantly in clinical presentation, sever...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1679de7f-f0f3-5898-81b6-e4953a12b7b1
DOI: 10.1101/2025.04.29.651203

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeted plasma proteomics uncover novel proteins associated with <i>KIF5A</i> -linked SPG10 and ALS spectrum disordersDOI 10.1101/2025.04.29.651203Read

Network Analysis of the Cerebrospinal Fluid Proteome Reveals Shared and Unique Differences Between Sporadic and Familial Forms of Amyotrophic Lateral SclerosisSemantic proximity Read

Plasma profiling reveals three proteins associated to amyotrophic lateral sclerosisSemantic proximity Read

Muscle proteins in plasma associate to distinguished phenotypes in amyotrophic lateral sclerosisSemantic proximity Read

Analysis of circulating protein aggregates reveals pathological hallmarks of amyotrophic lateral sclerosisSemantic proximity Read

Altered molecular and cellular mechanisms in KIF5A-associated neurodegenerative or neurodevelopmental disorders.Semantic proximity Read

Association of variants in the KIF1A gene with amyotrophic lateral sclerosisSemantic proximity Read

The Need for Biomarkers in the ALS–FTD Spectrum: A Clinical Point of View on the Role of ProteomicsSemantic proximity Read

One gene, many phenotypes: the role of KIF5A in neurodegenerative and neurodevelopmental diseases.Semantic proximity Read

Analysis of Circulating Protein Aggregates Reveals Pathological Hallmarks of Amyotrophic Lateral SclerosisSemantic proximity Read

Network analysis of the cerebrospinal fluid proteome reveals shared and unique differences between sporadic and familial forms of amyotrophic lateral sclerosisSemantic proximity Read

Mapping Parkinson’s Disease Progression through Deep Plasma Proteomics and Functional GenomicsSemantic proximity Read

Combined Tissue-Fluid Proteomics to Unravel Phenotypic Variability in Amyotrophic Lateral SclerosisSemantic proximity Read