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Phosphatidylserine externalization and procoagulant activation of erythrocytes induced by <i>Pseudomonas aeruginosa</i> virulence factor pyocyanin

19 Jan 2016

Abstract excerpt

The opportunistic pathogen Pseudomonas aeruginosa causes a wide range of infections in multiple hosts by releasing an arsenal of virulence factors such as pyocyanin. Despite numerous reports on the pleiotropic cellular targets of pyocyanin toxicity in vivo, its impact on erythrocytes remains elusive. Erythrocytes undergo an apoptosis-like cell death called eryptosis which is characterized by cell shrinkage and...

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PMID: 26781477
DOI: 10.1111/jcmm.12778

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