Influence of Sae-regulated and Agr-regulated factors on the escape of<i>Staphylococcus aureus</i>from human macrophages

Abstract excerpt

Although Staphylococcus aureus is not a classical intracellular pathogen, it can survive within phagocytes and many other cell types. However, the pathogen is also able to escape from cells by mechanisms that are only partially understood. We analysed a series of isogenic S. aureus mutants of the USA300 derivative JE2 for their capacity to destroy human macrophages from within. Intracellular S. aureus JE2 caused...

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